Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids

In tissue engineering, it is still rare today to see clinically transferable strategies for tissue-engineered graft production that conclusively offer better tissue regeneration than the already existing technologies, decreased recovery times, and less risk of complications. Here a novel tissue-engineering concept is presented for the production of living bone implants combining 1) a nanofibrous and microporous implant as cell colonization matrix and 2) 3D bone cell spheroids. This combination, double 3D implants, shows clinical relevant thicknesses for the treatment of an early stage of bone lesions before the need of bone substitutes. The strategy presented here shows a complete closure of a defect in nude mice calvaria after only 31 days. As a novel strategy for bone regenerative nanomedicine, it holds great promises to enhance the therapeutic efficacy of living bone implants

Photo- and Electron-Production of Mesons on Nucleons and Nuclei

In these lectures I will show some results obtained with the chiral unitary approach applied to the photo and electroproduction of mesons. The results for photoproduction of $\eta \pi^0 p$ and $K^0 \pi^0 \Sigma^+$, together with related reactions will be shown, having with common denominator the excitation of the $\Delta(1700)$ resonance which is one of those dynamically generated in the chiral unitary approach. Then I will show results obtained for the $e^+ e^- \to \phi f_0(980)$ reaction which reproduce the bulk of the data except for a pronounced peak, giving support to a new mesonic resonance, X(2175). Results will also be shown for the electromagnetic form factors of the $N^*(1535)$ resonance, also dynamically generated in this approach. Finally, I will show some results on the photoproduction of the $\omega$ in nuclei, showing that present experimental results claiming a shift of the $\omega$ mass in the medium are tied to a particular choice of background and are not conclusive. One the other hand, the same experimental results show unambiguously a huge increase of the $\omega$ width in the nuclear medium.Comment: Lecture at the "International School of Nuclear Physics", 29th Course Quarks in Hadrons and Nuclei, Erice, Italy, September 2007. Note added in Proofs concerning the mixed events technique and other comments on omega productio

De Haas-van Alphen effect and Fermi surface properties of single crystal CrB2

We report the angular dependence of three distinct de Haas-van Alphen (dHvA) frequencies of the torque magnetization in the itinerant antiferromagnet CrB2 at temperatures down to 0.3K and magnetic fields up to 14T. Comparison with the calculated Fermi surface of nonmagnetic CrB2 suggests that two of the observed dHvA oscillations arise from electron-like Fermi surface sheets formed by bands with strong B-px,y character which should be rather insensitive to exchange splitting. The measured effective masses of these Fermi surface sheets display strong enhancements of up to a factor of two over the calculated band masses which we attribute to electron-phonon coupling and electronic correlations. For the temperature and field range studied, we do not observe signatures reminiscent of the heavy d-electron bands expected for antiferromagnetic CrB2. In view that the B-p bands are at the heart of conventional high-temperature superconductivity in the isostructural MgB2, we consider possible implications of our findings for nonmagnetic CrB2 and an interplay of itinerant antiferromagnetism with superconductivity.Comment: 8 pages, 4 figure

On astrophysical solution to ultra high energy cosmic rays

We argue that an astrophysical solution to UHECR problem is viable. The pectral features of extragalactic protons interacting with CMB are calculated in model-independent way. Using the power-law generation spectrum $\propto E^{-\gamma_g}$ as the only assumption, we analyze four features of the proton spectrum: the GZK cutoff, dip, bump and the second dip. We found the dip, induced by electron-positron production on CMB, as the most robust feature, existing in energy range $1\times 10^{18} - 4\times 10^{19}$ eV. Its shape is stable relative to various phenomena included in calculations. The dip is well confirmed by observations of AGASA, HiRes, Fly's Eye and Yakutsk detectors. The best fit is reached at $\gamma_g =2.7$, with the allowed range 2.55 - 2.75. The dip is used for energy calibration of the detectors. After the energy calibration the fluxes and spectra of all three detectors agree perfectly, with discrepancy between AGASA and HiRes at $E> 1\times 10^{20}$ eV being not statistically significant. The agreement of the dip with observations should be considered as confirmation of UHE proton interaction with CMB. The dip has two flattenings. The high energy flattening at $E \approx 1\times 10^{19}$ eV automatically explains ankle. The low-energy flattening at $E \approx 1\times 10^{18}$ eV provides the transition to galactic cosmic rays. This transition is studied quantitatively. The UHECR sources, AGN and GRBs, are studied in a model-dependent way, and acceleration is discussed. Based on the agreement of the dip with existing data, we make the robust prediction for the spectrum at $1\times 10^{18} - 1\times 10^{20}$ eV to be measured in the nearest future by Auger detector.Comment: Revised version as published in Phys.Rev. D47 (2006) 043005 with a small additio

Proton polarizability effect in the Lamb shift of the hydrogen atom

The proton polarizability correction to the Lamb shift of electronic and muonic hydrogen is calculated on the basis of isobar model and experimental data on the structure functions of deep inelastic lepton-nucleon scattering. The contributions of the Born terms, vector-meson exchanges and nucleon resonances are taken into account in the construction of the photoabsorption cross sections for transversely and longitudinally polarized virtual photons sigma_{T,L}.Comment: 11 pages, 3 figure

The Generalized Gerasimov-Drell-Hearn Integral and the Spin Structure of the Nucleon

The spin structure functions g1 and g2 have been calculated in the resonance region and for small and intermediate momentum transfer. The calculation is based on a gauge-invariant and unitary model for one-pion photo- and electroproduction. The predictions of the model agree with the asymmetries and the spin sturcture functions recently measured at SLAC, and the first moments of the calculated spin structure functions fullfil the Gerasimov-Drell-Hearn and Burkhardt-Cottingham sum rules within an error of typically 5-10 %.Comment: 22 pages LATEX including 5 postscript figures, replaced with 2 new figure

Imaging thrombosis with 99mTc-labeled RAM.1-antibody in vivo.

Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represent the major causes of death worldwide. The aim of this study was to evaluate the specificity of radiolabeled Rat-Anti-Mouse antibody (RAM.1).We describe a method to detect platelets by using a RAM.1 coupled with the chelating agent hydrazinonicotinic acid (HYNIC) conjugated toWe demonstrated a quick and strong affinity of the radiolabeled RAM.1 for the platelet thrombus. Results clearly demonstrated the ability of this radioimmunoconjugate for detecting thrombi from 10 min post injection with an exceptional thrombi uptake. Using FeClThanks to the high sensitivity of SPECT, we provided evidence that [journal articleresearch support, non-u.s. gov't2018 062018 03 17importe

GATE : a simulation toolkit for PET and SPECT

Monte Carlo simulation is an essential tool in emission tomography that can assist in the design of new medical imaging devices, the optimization of acquisition protocols, and the development or assessment of image reconstruction algorithms and correction techniques. GATE, the Geant4 Application for Tomographic Emission, encapsulates the Geant4 libraries to achieve a modular, versatile, scripted simulation toolkit adapted to the field of nuclear medicine. In particular, GATE allows the description of time-dependent phenomena such as source or detector movement, and source decay kinetics. This feature makes it possible to simulate time curves under realistic acquisition conditions and to test dynamic reconstruction algorithms. A public release of GATE licensed under the GNU Lesser General Public License can be downloaded at the address http://www-lphe.epfl.ch/GATE/

Parity-Violating Excitation of the \Delta(1232): Hadron Structure and New Physics

We consider prospects for studying the parity-violating (PV) electroweak excitation of the \Delta(1232) resonance with polarized electron scattering. Given present knowledge of Standard Model parameters, such PV experiments could allow a determination of the N -> \Delta electroweak helicity amplitudes. We discuss the experimental feasibility and theoretical interpretability of such a determination as well as the prospective implications for hadron structure theory. We also analyze the extent to which a PV N -> \Delta measurement could constrain various extensions of the Standard Model.Comment: 43 pages, RevTex, 8 PS figures, uses epsf.sty, rotate.sty, version to appear in Nucl. Phys. A, main points emphasized, some typos correcte

BERITA ANTASARI DI KOMPAS DAN CITRA KPK

Criminalization of the Komisi Pemberantasan Korupsi (KPK) began with the Antasari Azhar who stuck a murder case, the preaching of the Antasari can change perceptions about the task, status, organization, powers and responsibilities of the KPK. This can cause a wide gap between the demands and expectations of the quality of the image KPK KPK in the news media. The newspaper is a media that provides complete information than other media. Discussions sharply news and interesting ideas are always written in the newspaper. News Antasari is one of the interesting news and shake your body warm because the KPK is shown as much as 24 times the headlines by the newspaper Kompas in which, in preaching about Antasari Azhar case involved a murder case, biography Antasari in handling various cases of corrupt law and also information about our Commission as guidance as and protector of society. The purpose of this study is to describe student perceptions of member Badan Eksekutif Mahasiswa (BEM) Faculty of Law University of Sebelas Maret surakarta on the image of the KPK after using the daily newspaper Kompas on news Antasari in May - June 2009 This study uses an explanatory type of research that describes the relationship between variables by testing the hypothesis that has been previously formulated. Respondents in this study represents the total number of student members of BEM Faculty of Law which is still active in the BEM Faculty of Law, Sebelas Maret University and read about the news Antasari. In a study using the technique of this censusas many as 40 people found the respondent. While the analysis used to test cross-tabulation correlation formula From the cross tabulation test results,showed a significant relationship between use of the Kompas daily newspaper with students' perceptions on the image of KPK. and showed a significant relationship between external factors that include social groups and other mass media's role in students' perceptions on the image of the KPK after using Antasari news in Kompas